Methyl Isocyanate → HCID 14232110, compound

Participants

Reaction Conditions

Reaction Steps

A solution containing 4 g of N-(1H-pyrrol-1-yl)-4-pyridinamine 1.6 g of methyl isocyanate in 125 ml of benzene was stirred at 50° C. for two hours, and thereafter cooled and evaporated to 6 g of a solid. This material was purified by HPLC (silica gel, 50% ethyl acetate in dichloromethane) to give 5 g of a solid, mp 156°-160° C. This material was recrystallized twice from benzene to give 2.6 g of crystals, mp 162°-163° C.

Provenance & Evidence