HuagongsheHuagongshe Chemistry Print Report · For research reference only
Khellinone → 1-(6-hydroxy-4,7-dimethoxy-2,3-dihydro-1-benzofuran-5-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Khellinone | HCID 68086 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(6-hydroxy-4,7-dimethoxy-2,3-dihydro-1-benzofuran-5-yl)ethanone | HCID 243769 | 96.2% |
Reaction Steps
10 g of 5-acetyl-6-hydroxy-4,7-dimethoxybenzofuran in 100 ml of methanol are hydrogenated using 2 g of Pd/C (10%) at room temperature and under slightly superatmospheric pressure. When the absorption of hydrogen is complete, the mixture is filtered and the solvent is distilled off. 9.7 g of the desired product of melting point 100°-101° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05039701 |
| Source dataset | uspto-grants-1991_08 |
| ORD ID | ord-11488d71069e483089f9d718cff5c091 |
| Source note | uspto-grants-1991_08 |