HCID 19996065, compound → HCID 19996126, compound

HRID 2248402Notes

Reaction equation

HRID 2248402 reaction equation
[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([CH:9]([OH:34])[CH2:10][NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][CH2:21][C:22]2[O:26][C:25]([C:27]([N:29]([CH2:32][CH3:33])[CH2:30][CH3:31])=O)=[CH:24][CH:23]=2)=[CH:4][C:3]=1[Cl:35].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1C=CC=CC=1.CCOCC>[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([CH:9]([CH2:10][NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][CH2:21][C:22]2[O:26][C:25]([CH2:27][N:29]([CH2:30][CH3:31])[CH2:32][CH3:33])=[CH:24][CH:23]=2)[OH:34])=[CH:4][C:3]=1[Cl:35]

Participants

5

Reactant 2

HCID 19996065HCID 19996065, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 19996126HCID 19996126, compoundYield 73%

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 3283Diethyl EtherSolvent

Procedure

A solution of 5-[3-[[6-[[2-(4-amino-3,5-dichlorophenyl)-2-hydroxyethyl]amino]hexyl]oxy]propyl]-N,N-diethyl-2-furancarboxamide (0.83 g) in benzene (6 ml) was added dropwise over 10 min to a stirred suspension of lithium aluminium hydride (175 mg) in dry ether (15 ml) under nitrogen. The mixture was stirred under nitrogen at 22° for 24h, then quenched sequentially with water (1 ml), 2N sodium hydroxide solution (1 ml) and water (2 ml). The mixture was filtered through hyflo and the solids washed with toluene-ether (1:1, 10 ml). The combined filtrate and washings were dried and evaporated in vacuo to an oil. Purification by FCC eluting with System C (93:5:2) afforded the title compound as a pale yellow oil (0.59 g), t.l.c. (System A 39:10:1) Rf 0.5.

Workup

  1. customquenched sequentially with water (1 ml), 2N sodium hydroxide solution (1 ml) and water (2 ml)
  2. filtrationThe mixture was filtered through hyflo
  3. washthe solids washed with toluene-ether (1:1, 10 ml)
  4. customThe combined filtrate and washings were dried
  5. customevaporated in vacuo to an oil
  6. customPurification by FCC
  7. washeluting with System C (93:5:2)

Sources & evidence

ORD record
ord-df93c17214a34285b6355a15f24044d4
Source dataset
uspto-grants-1991_08
Patent number
US05039697

Reaction notes

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