4-Methylbenzenethiol → HCID 10469390, compound

HRID 2248408Notes

Reaction equation

HRID 2248408 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.Cl[CH2:10][CH2:11][CH2:12][C:13]([C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=1)=[O:14]>>[F:21][C:18]1[CH:17]=[CH:16][C:15]([C:13](=[O:14])[CH2:12][CH2:11][CH2:10][S:8][C:5]2[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][CH:4]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 78114-MethylbenzenethiolHCID 197503-(4-Fluorobenzoyl)propyl chloride

Product 1

HCID 10469390HCID 10469390, compoundYield 100%

Procedure

The title compound (58.0 g, 100%) was prepared from 4-thiocresol and 4-chloro-4'-fluorobutyrophenone as described in Example 2 as an oil; IR(neat): C=O @ 1700 cm-1 ; NMR(DMSO-d6, TMS): δ 1.8-1.95(m,2H, CH2), 2.26(s,3H,ArCH3), 2.98(t,2H,CH2 --CO), 3.16(t,2H,S--CH2), 7.1-8.1(m,8H, aromatic); mass spectrum m/e 288.

Sources & evidence

ORD record
ord-95007ae1c9f742d8a4143d1b0cf1b685
Source dataset
uspto-grants-1991_08
Patent number
US05039706

Reaction notes

Loading…