Butylamine → Urea, 1-butyl-3-methyl-

HRID 2248416Notes

Reaction equation

HRID 2248416 reaction equation
[CH2:1]([NH2:5])[CH2:2][CH2:3][CH3:4].[CH3:6][N:7]=[C:8]=[O:9]>ClCCl>[CH3:6][NH:7][C:8]([NH:5][CH2:1][CH2:2][CH2:3][CH3:4])=[O:9]

Participants

4

Reactant 2

HCID 8007ButylamineHCID 12228Methyl Isocyanate

Product 1

HCID 96349Urea, 1-butyl-3-methyl-

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

280.32 Grams (3.84 moles) of butylamine and 300 ml of dichloromethane were charged to a round bottom flask equipped with stirrer, cold bath, thermometer, addition funnel and reflux condenser. 229.8 Grams (4.03 Moles, a 5% excess) of methyl isocyanate were charged to the addition funnel and added to the flask contents over four hours keeping the contents between 0° and 35° C. After an additional hour of stirring the exothermic reaction subsided and the mixture was allowed to stand overnight.

Workup

  1. customequipped with stirrer, cold bath
  2. additionthermometer, addition funnel
  3. temperaturereflux condenser
  4. additionadded to the flask contents over four hours
  5. customthe contents between 0° and 35° C
  6. customthe exothermic reaction

Sources & evidence

ORD record
ord-080c71fea25e40c69e355a8fc2a44dee
Source dataset
uspto-grants-1991_08
Patent number
US05039759

Reaction notes

Loading…