HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → (4-Hydroxy-3,5-dimethylphenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 4'-Hydroxy-3',5'-dimethylacetophenone | HCID 36581 | — |
| Reactant | Sulfur | HCID 5362487 | — |
| Reactant | 2-Hydroxyethylamide | HCID 86733662 | — |
| Product | (4-Hydroxy-3,5-dimethylphenyl)acetic acid | HCID 16767514 | — |
Reaction Steps
2-(4-Hydroxy-3,5-dimethylphenyl)acetic acid is prepared in a known way (cf. J. Org. Chem. 11, 798 (1946)) from 4-acetyl-2,6-dimethylphenol, sulfur, and morpholine (Willgeroth-Kindler Reaction) and has a melting point of 147° C. The acid is converted into the 2-hydroxyethylamide (yellow-brown oil) through the methyl ester (melting point 95° C.) by the method of Example 1.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05039781 |
| Source dataset | uspto-grants-1991_08 |
| ORD ID | ord-3c8dd07750914882917d110df1e42932 |
| Source note | uspto-grants-1991_08 |