Hydrochloric Acid → HCID 19996497, compound

Participants

Reaction Steps

N1 -Propionyl-4,6-dimethyl-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl) methyl]sulfinyl]-1H-benzimidazole (1.0 g, 0.0023 mol) was heated in 1M NaOH (15 ml) for 1 h under stirring and N2 -atmosphere. pH was adjusted to 9.5 by addition of 2M HCl. Extraction with CH2Cl2, separation of the phases, drying the organic phase, evaporation of the solvent and recrystallization from CH3CN gave the desired product (0.30 g, 35%), m.p. 137° C.

Provenance & Evidence