Ethanol → HCID 19996527, compound

Participants

Reaction Steps

A solution of potassium hydroxide [51 g (1.1 mol) in 50 ml of water] was added to a stirred solution of 4-trifluoromethyl-1-(2,6-dichloro-4-ethoxycarbonylphenyl)-2-pyridone (Compound C) in ethanol [35 g (0.09 mol) in 500 ml of ethanol]. The reaction was stirred for one hour at room temperature. The ethanol mixture was removed in vacuo and the residue treated with dilute HCl and extracted with ethylacetate (2×300 ml). The combined organic portions, were washed well with water, dried over magnesium sulphate and evaporated in vacuo to give a white solid of 4-trifluoromethyl-1-(2,6-dichloro-4-carboxyphenyl)-2-pyridone (31.3 g).

Provenance & Evidence