HCID 19768447, compound → HCID 19768457, compound

HRID 2248457Notes

Reaction equation

HRID 2248457 reaction equation
[ClH:1].[O:2]=[C:3]1[NH:8][CH:7]=[C:6]([C:9]2([NH:15]C=O)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:5]=[CH:4]1>CO>[ClH:1].[NH2:15][C:9]1([C:6]2[CH:5]=[CH:4][C:3](=[O:2])[NH:8][CH:7]=2)[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]1

Participants

3

Reactant 1

HCID 19768447HCID 19768447, compound

Product 1

HCID 19768457HCID 19768457, compoundYield 14.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of N-[1-(1,6-dihydro-6-oxo-3-pyridinyl)cyclohexyl]formamide hydrochloride (43.0 g) in 700 ml of methanol was heated at reflux for 17 hours, and then cooled and concentrated. The residual oil was triturated with methanol affording 13.1 g of a white powder. Recrystallization from methanol gave 5.5 g of crystals, m.p. 233°-234° C.

Workup

  1. temperatureat reflux for 17 hours
  2. temperaturecooled
  3. concentrationconcentrated
  4. customThe residual oil was triturated with methanol affording 13.1 g of a white powder
  5. customRecrystallization from methanol

Sources & evidence

ORD record
ord-a8fb5069db674cdfa05a82686b99796f
Source dataset
uspto-grants-1991_08
Patent number
US05039809

Reaction notes

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