HCID 19768455, compound → HCID 19768453, compound

HRID 2248458Notes

Reaction equation

HRID 2248458 reaction equation
[ClH:1].[O:2]=[C:3]1[NH:8][CH:7]=[C:6]([C:9]2([NH:17]C=O)[CH2:14][CH2:13][C:12]([CH3:16])([CH3:15])[CH2:11][CH2:10]2)[CH:5]=[CH:4]1>CO>[ClH:1].[NH2:17][C:9]1([C:6]2[CH:5]=[CH:4][C:3](=[O:2])[NH:8][CH:7]=2)[CH2:14][CH2:13][C:12]([CH3:16])([CH3:15])[CH2:11][CH2:10]1

Participants

3

Reactant 1

HCID 19768455HCID 19768455, compound

Product 1

HCID 19768453HCID 19768453, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of N-[1-(1,6-dihydro-6-oxo-3-pyridinyl)-4,4-dimethylcyclohexyl]formamide hydrochloride (7.05 g) in 125 ml of methanol was heated at reflux for 24 hours, and then the solution was cooled and concentrated in vacuo to a volume of 25 ml. The precipitated powder was collected, affording 3.07 g of analytically pure 5-(1-amino-4,4-dimethylcyclohexyl)-2(1H)-pyridinone hydrochloride, m.p. 229°-230° C.

Workup

  1. temperatureat reflux for 24 hours
  2. temperaturethe solution was cooled
  3. concentrationconcentrated in vacuo to a volume of 25 ml
  4. customThe precipitated powder was collected

Sources & evidence

ORD record
ord-65deddb6d9944dfdb268b1920762e1d6
Source dataset
uspto-grants-1991_08
Patent number
US05039809

Reaction notes

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