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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2248466Generated: October 26, 2026

Hydrochloric Acid → Alendronic Acid

https://huagongshe.com/reaction/2248466

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantTetramethyl phthalimido-1-hydroxybutylidene-bisphosphonateHCID 9845824—
ProductAlendronic AcidHCID 2088—

Reaction Steps

contacting tetramethyl phthalimido-1-hydroxybutylidene-bisphosphonate from Step (b) with aqueous hydrochloric acid at a temperature range of 80° C. to reflux to form 4-amino-1-hydroxybutylidene-bisphosphonic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05039819
Source datasetuspto-grants-1991_08
ORD IDord-99beb0c1a7ae47a28f2e02c0adfa46b0
Source noteuspto-grants-1991_08