N-((1,1-dimethylethoxy)carbonyl)-beta-alanine → 5-[3-(1-t-Butoxyformamido)propionamido]-2-nitrobenzoic acid

Participants

Reaction Steps

For the preparation of the ester starting material, MS: 468 (18, M+NH4), 451 (100, M+H), N-(t-butoxycarbonyl)-β-alanine and 5-amino-2-nitrobenzoic acid are reacted to give 5-[3-(1-t-butoxyformamido)propionamido]-2-nitrobenzoic acid, MS: 354 (17, M+H), the latter is reacted with β-alanine t-butyl ester to give N-[5-[3-(1-t-butoxyformamido)propionamido]-2-nitrobenzoyl]-β-alanine t-butyl ester and this is hydrogenated on Pd/C in ethanol.

Provenance & Evidence