Trifluoroacetic acid → HCID 67827898, compound

Participants

Reaction Steps

A solution of 55 mg of N-[N-[m-[[3-(p-amidinophenyl)-N-(t-butoxycarbonyl)-DL-alanyl]amino]benzoyl]-3-(t-butoxycarbonyl)-L-alanyl]-3-(1-naphthyl)-L-alanine (1:1 epimer) in a mixture of 10 ml of methylene chloride and 5 ml of trifluoroacetic acid is held at room temperature for 2 hours while gassing with argon. After evaporation of the solvent there is obtained N-[N-[m-[[3-(p-amidinophenyl)-DL-alanyl]amino]benzoyl]-L-α-aspartyl]-3-(1-naphthyl)-L-alanine trifluoroacetate (1:2), m.p. 165° C. (dec.) (ethanol/ethyl acetate), yield: 84% of theory, MS: 639 (M+H)+.

Provenance & Evidence