HCID 139627354, compound → HCID 19996358, compound

Participants

Reaction Steps

173 mg of N-[4-(benzyloxy)-3-[p-[N-(t-butoxycarbonyl)amidino]benzamido]benzoyl]-β-alanine in 4 ml of formic acid are stirred at 20° C. for 4 hours. The reaction mixture is evaporated in a vacuum, the residue is suspended in water and adjusted to pH 8-9 with ammonia. After stirring for a short time the mixture is suction filtered, the filter residue is washed with water and dried at 50° C. in a vacuum. There are obtained 136 mg of N-[3-(p-amidinobenzamido)-4-(benzyloxy)benzoyl]-β-alanine, m.p. >250° C., MS: 461 (41, M+H), as a hydrate (1:1).

Provenance & Evidence