Aspirin → Aspirin Sodium Warfarin
Reaction equation
[CH3:1][C:2]([O:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:10]=1[C:11]([OH:13])=[O:12])=[O:3].[CH3:14][C:15]([CH2:17][CH:18]([C:25]1[C:34](=[O:35])[O:33][C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:26]=1[O-:36])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16].[Na+:37].C(OCCCCCCCCCCCCCCCCCC)(=O)/C=C/C([O-])=O.[Na+]>>[CH3:1][C:2]([O:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:10]=1[C:11]([OH:13])=[O:12])=[O:3].[CH3:14][C:15]([CH2:17][CH:18]([C:25]1[C:34](=[O:35])[O:33][C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:26]=1[O-:36])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16].[Na+:37]Participants
Procedure
Prior to weighing, pass all ingredients though an appropriate screen as needed. Weight all ingredients and place the sustained release coated aspirin, one-half of the microcrystalline cellulose, colloidal silica and sodium starch glycolate into a twin-shell blender, and mix for about 15 minutes. Combine the sodium warfarin with the remaining microcrystalline cellulose, colloidal silica, and sodium starch glycolate and mix for about 15 minutes. Add one-half of the sodium stearyl fumarate to the sodium warfarin blend and blend for about 3 minutes. Slug this blend using 1/2 inch flat-face punches and mill. Combine the aspirin blend with the sodium warfarin granulation and mix for about 10 minutes in a twin-shell blender. Add the remaining sodium stearyl fumarate, mix for about 3 minutes and either compress the blend into tablets or place into capsules. It should be noted that the microcrystalline cellulose in this formulation is adjusted such that the total dosage form weight is 403.0 mg.
Workup
- additionmix for about 10 minutes in a twin-shell blender
- additionmix for about 3 minutes
Sources & evidence
- ORD record
- ord-e847c1b8649a4426a99ed7bae1ce77b0
- Source dataset
- uspto-grants-1991_08
- Patent number
- US05041430
Reaction notes
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