Sodium Acetate → HCID 11722937, compound

HRID 2248565Notes

Reaction equation

HRID 2248565 reaction equation
[CH2:1]([N:3]([CH2:21][CH3:22])[C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18](O)=[O:19])(=[O:12])=[O:11])=[CH:6][CH:5]=1)[CH3:2].C([O-])(=O)C.[Na+]>C(OC(=O)C)(=O)C>[CH2:1]([N:3]([CH2:21][CH3:22])[C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH2:14][CH2:15][CH2:16][CH2:17][C:18]2=[O:19])(=[O:12])=[O:11])=[CH:6][CH:5]=1)[CH3:2]

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 10471725HCID 10471725, compound

Product 1

HCID 11722937HCID 11722937, compoundYield 63.5%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

2 g of product obtained in stage A are heated to reflux for 2 hours with 2 g of sodium acetate in 20 cm3 of acetic anhydride. The mixture is cooled to room temperature and evaporated to dryness, the residue is taken up in a mixture of chloroform and water, the organic phase is separated and dried and, after removal of the solvents, 1.8 g of expected crude product are obtained. M.p. 118°-120° C. After crystallization in isopropanol, 1.2 g of pure product are obtained. M.p. 122°-123° C.

Workup

  1. customevaporated to dryness
  2. additionthe residue is taken up in a mixture of chloroform and water
  3. customthe organic phase is separated
  4. customdried
  5. customafter removal of the solvents, 1.8 g of expected crude product
  6. customare obtained
  7. customAfter crystallization in isopropanol

Sources & evidence

ORD record
ord-97ca80101dee408eb2e25958f4337bf2
Source dataset
uspto-grants-1991_08
Patent number
US05041436

Reaction notes

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