Sodium Acetate → HCID 19994506, compound

HRID 2248567Notes

Reaction equation

HRID 2248567 reaction equation
[CH2:1]([N:4]([CH2:22][CH2:23][CH3:24])[C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19](O)=[O:20])(=[O:13])=[O:12])=[CH:7][CH:6]=1)[CH2:2][CH3:3].C([O-])(=O)C.[Na+]>C(OC(=O)C)(=O)C>[CH2:1]([N:4]([CH2:22][CH2:23][CH3:24])[C:5]1[CH:10]=[CH:9][C:8]([S:11]([N:14]2[CH2:15][CH2:16][CH2:17][CH2:18][C:19]2=[O:20])(=[O:13])=[O:12])=[CH:7][CH:6]=1)[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 19994509HCID 19994509, compound

Product 1

HCID 19994506HCID 19994506, compoundYield 92.7%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

5 g of product obtained in Stage A are heated to reflux for 2 hours with 5 g of sodium acetate in 50 cm3 of acetic anhydride. The mixture is cooled to room temperature and evaporated to dryness, the residue is taken up in 50 cm3 of water and dried and 4.4 g of expected product are obtained. M.p. 105°-108° C. after chromatography on silica (eluent: ethyl acetate/n-hexane, 1:1). After crystallization in isopropanol, 3.2 g of pure product are obtained. M.p. 110°-111° C.

Workup

  1. customevaporated to dryness
  2. customdried

Sources & evidence

ORD record
ord-2a10eaf841984481a5637ed701406411
Source dataset
uspto-grants-1991_08
Patent number
US05041436

Reaction notes

Loading…