5-Aminovaleric acid → HCID 19994505, compound

Participants

Reaction Steps

4.5 g of 4-azacyclooctylbenzenesulphonyl chloride are added to a solution comprising 1.82 g of 5-aminovaleric acid and 1.87 g of sodium hydroxide dissolved in 45 cm3 of water, followed by the addition of 45 cm3 of tetrahydrofuran in order to obtain a solution. The mixture is kept stirred for 2 hours at room temperature, the tetrahydrofuran is evaporated off, the reaction medium is acidified using acetic acid, the precipitate is filtered off, washed with water and dried and 3.6 g of expected product are obtained. M.p. 149°-150° C. After crystallization in an isopropanol/water mixture (1:1), the product, melting point 153°-154° C., is obtained.

Provenance & Evidence