Corticosterone → HCID 14507149, compound

HRID 2248582Notes

Reaction equation

HRID 2248582 reaction equation
[CH3:1][C@@:2]12[C@H:12]3[C@@H:13]([OH:25])[CH2:14][C@:15]4([CH3:24])[C@@H:19]([C:20](CO)=[O:21])[CH2:18][CH2:17][C@H:16]4[C@@H:11]3[CH2:10][CH2:9][C:8]1=[CH:7][C:5](=[O:6])[CH2:4][CH2:3]2.CC(C)=[O:28].OS(O)(=O)=O.O=[Cr](=O)=O>CC(C)=O>[CH3:24][C@:15]12[CH2:14][C:13](=[O:25])[C@H:12]3[C@@H:11]([CH2:10][CH2:9][C:8]4[C@:2]3([CH3:1])[CH2:3][CH2:4][C:5](=[O:6])[CH:7]=4)[C@@H:16]1[CH2:17][CH2:18][C@@H:19]2[C:20]([OH:28])=[O:21]

Participants

4

Reactant 2

HCID 5753CorticosteroneHCID 131709961Jones' reagent

Product 1

HCID 14507149HCID 14507149, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Alternatively, corticosterone, in an appropriate solvent such as acetone, may be treated directly with Jones reagent to yield androst-4-ene-3,11-dione-17β-carboxylic acid.

Sources & evidence

ORD record
ord-59dcd6f4266f4201ba4c6ed2ca7010e1
Source dataset
uspto-grants-1991_08
Patent number
US05041433

Reaction notes

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