1,2-Dimethoxyethane → Pyridine-2,3-dicarboxamide

Participants

Reaction Steps

Pyridine diamide 3 was prepared according to the general procedure described in Example 8 using 2-(aminomethyl)pyridine (0.015 mol), 2-chloro-N,N-dihexylacetamide (0.048 mol), diisopropylethylamine (0.033 mol) and dimethoxyethane (25 mL). The product was isolated from a heptane extraction of the acidic aqueous layer. The product was made basic by extraction with aqueous NaOH. The organic solution was concentrated, and the residue was distilled (200° C., 0.05 mm) to afford 6.1 g of pure product.

Provenance & Evidence