Lawesson's reagent → HCID 14810917, compound

Participants

Reaction Steps

1-Methylindole-3-carboxamide (0.6 g) was suspended in toluene (20 ml): Lawesson's Reagent (0.7 g) was added and the mixture was heated at reflux under nitrogen for 30 min until dissolution occurred. The solution was cooled and toluene was removed under reduced pressure. The orange residue was purified by column chromatography on alumina using CH2Cl2 as eluant. This afforded an orange crystalline material, (0.5 g). δH (360 MHz, DMSO-d6) 3.82 (3 H, s, NCH3), 7.18 and 7.23 (2 H, 2×dt, J=7.1, 1.1 Hz, H-5 and H-6), 7.49 (1 H. d, J=7.5 Hz, H-7), 8.08 (1 H, s, H-2), 8.59 (1 H, d, J=7.5 Hz, H-4), 8.76 (2 H, brs, NH2); m/z 190 (M+, 100%), 174 (20), 157 (80).

Provenance & Evidence