2-Propanethiol → HCID 67934946, compound

Participants

Reaction Steps

A solution of 1.83 g (8.9 mmol) of 4-fluoro-N-(1H-1,2,4-triazol-1-yl)-benzamide and 1.05 g (8.9 mmol) of phosphorous pentachloride and 20 mL of phosphorous oxychloride is heated at reflux for 1 h. Solvent is stripped and the residue dissolved in 30 mL of benzene. Triethylamine (1.4 mL, 10 mmol) and 1.0 g (13 mmol) of isopropyl mercaptan is added and the solution is heated at reflux for 4 h. The solution is diluted with ethyl acetate and washed with water and brine. Drying (MgSO4) and removal of solvent gives product which is purified by chromatography on silica gel.

Provenance & Evidence