Iodine → HCID 19994945, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1.3 g (12.8 mmol) of diisopropyl amine in 30 mL is cooled to -78° C. n-Butyllithium (4.3 mL of a 1.6M solution in hexanes, 6.9 mmol) is added dropwise. Over 1/2 h, the solution is warmed to 0° C. and recooled to -78° C. A solution of 2.0 g (6.3 mmol) of N-(1H-1,2,4-triazol-1-yl)-benzophenone imine in 5 mL of tetrahydrofuran is added. The solution is stirred 10 min before 1.7 g (6.7 mmol) of iodine are added. The reaction mixture is warmed to room temperature, diluted with ethyl acetate and washed with saturated aqueous NaHSO3, water and brine. Drying (MgSO4) and removal of solvent gives the desired product.

Provenance & Evidence