HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 19075361, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Hexyn-1-ol | HCID 66083 | — |
| Reactant | 3-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole | HCID 10488164 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 19075361 | HCID 19075361 | — |
Reaction Steps
To a solution of 3-hexyn-1-ol (880 mg, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 1 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05041455 |
| Source dataset | uspto-grants-1991_08 |
| ORD ID | ord-3f0b60573df84e929dac29d0a72bd4e3 |
| Source note | uspto-grants-1991_08 |