反应详情

2-Chloro-4-cyanopyridine (115.53 g) in methanol/dioxan (1:1, 850 ml) was added to a solution of sodium methoxide (prepared from 20.8 g sodium) in methanol (285 ml) and the mixture was boiled under reflux for 2.5 hours and was allowed to cool. The mixture was filtered and the volume of the filtrate was reduced by evaporation to 200 ml and water (400 ml) was added. The solid which precipitated out was filtered off to give 2-methoxy-4-cyanopyridine (57.2 g, 51%) m.p. 93°-95.5°.

1. temperatureunder reflux for 2.5 hours
2. temperatureto cool
3. filtrationThe mixture was filtered
4. customthe volume of the filtrate was reduced by evaporation to 200 ml and water (400 ml)
5. additionwas added
6. customThe solid which precipitated out
7. filtrationwas filtered off