Ammonia → HCID 14986257, compound

HRID 2248760Notes

Reaction equation

HRID 2248760 reaction equation
C([O:4][CH2:5][C:6]([NH:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([NH:17][CH2:18][CH3:19])[C:10]=1[C:11]#[N:12])=[O:7])(=O)C.N>CO>[CH2:18]([NH:17][C:13]1[CH:14]=[CH:15][CH:16]=[C:9]([NH:8][C:6](=[O:7])[CH2:5][OH:4])[C:10]=1[C:11]#[N:12])[CH3:19]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14986256HCID 14986256, compound

Product 1

HCID 14986257HCID 14986257, compoundYield 68.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-(acetoxyacetylamino)-6-(ethylamino)benzonitrile (4.5 g) in methanol (250 ml) is added dropwise 28% aqueous ammonia (5.5 ml). The mixture is stirred at room temperature for 1 hour, and thereafter, the solvent is distilled off under reduced pressure. The resulting crude crystals are recrystallized from ethanol to give the title compound (2.6 g) having the following physical properties.

Workup

  1. distillationthe solvent is distilled off under reduced pressure
  2. customThe resulting crude crystals are recrystallized from ethanol

Sources & evidence

ORD record
ord-9e04d429d69948f298901c5a1b42029f
Source dataset
uspto-grants-1991_08
Patent number
US05041462

Reaction notes

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