Water → 2-(acetoxyacetylamino)-6-(N-ethyl-N-methylamino)benzonitrile

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Reaction Steps

To a solution of 2-amino-6-(N-ethyl-N-methylamino)-benzonitrile (4 g) in methylene chloride (200 ml) is added pyridine (2.4 ml), and thereto is added dropwise acetoxyacetyl chloride (3.3 ml) which is cooled in an ice bath. The mixture is stirred at room temperature for 1 hour, and thereafter, water is added thereto, and the mixture is extracted with methylene chloride. The organic layer is dried over anhydrous sodium sulfate, and the solvent is distilled off under reduced pressure. The resulting residue is recrystallized from hexane to give the title compound (4.2 g) having the following physical properties.

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