Ammonia → HCID 14986267, compound

HRID 2248768Notes

Reaction equation

HRID 2248768 reaction equation
C([O:4][CH2:5][C:6]([NH:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([NH:17][C:18](=[O:24])[CH2:19][O:20]C(=O)C)[C:10]=1[C:11]#[N:12])=[O:7])(=O)C.N>CO>[OH:4][CH2:5][C:6]([NH:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([NH:17][C:18](=[O:24])[CH2:19][OH:20])[C:10]=1[C:11]#[N:12])=[O:7]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14986266HCID 14986266, compound

Product 1

HCID 14986267HCID 14986267, compoundYield 75.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2,6-bis(acetoxyacetylamino)benzonitrile (6.7 g) in methanol (700 ml) is added dropwise 28% aqueous ammonia (10 ml). The mixture is stirred at room temperature for 1 hour, and thereafter, the solvent is distilled off under reduced pressure. The resulting crude crystals are recrystallized from ethanol to give the title compound (3.8 g) having the following physical properties.

Workup

  1. distillationthe solvent is distilled off under reduced pressure
  2. customThe resulting crude crystals are recrystallized from ethanol

Sources & evidence

ORD record
ord-ceea9c2f8b9a44d482f80e6cbbc8c295
Source dataset
uspto-grants-1991_08
Patent number
US05041462

Reaction notes

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