Ammonia → HCID 14986275, compound

HRID 2248769Notes

Reaction equation

HRID 2248769 reaction equation
C([O:4][CH2:5][C:6]([NH:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[C:10]=1[C:11]#[N:12])=[O:7])(=O)C.N>CO>[OH:4][CH2:5][C:6]([NH:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[C:10]=1[C:11]#[N:12])=[O:7]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14986281HCID 14986281, compound

Product 1

HCID 14986275HCID 14986275, compoundYield 86.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-(acetoxyacetylamino)-6-methoxybenzonitrile (2.5 g) in methanol (250 ml) is added dropwise 28%aqueous ammonia (5 ml). The mixture is stirred at room temperature for 1 hour, and thereafter, the solvent is distilled off under reduced pressure. The resulting crude crystals are recrystallized from ethanol to give the title compound (1.8 g) having the following physical properties.

Workup

  1. distillationthe solvent is distilled off under reduced pressure
  2. customThe resulting crude crystals are recrystallized from ethanol

Sources & evidence

ORD record
ord-9a4212fcece84e8a997a4709c99776f4
Source dataset
uspto-grants-1991_08
Patent number
US05041462

Reaction notes

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