Ammonia → HCID 14986276, compound

HRID 2248770Notes

Reaction equation

HRID 2248770 reaction equation
C([O:4][CH2:5][C:6]([NH:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[C:10]=1[C:11]#[N:12])=[O:7])(=O)C.N>CO>[OH:4][CH2:5][C:6]([NH:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([N:17]2[CH2:18][CH2:19][O:20][CH2:21][CH2:22]2)[C:10]=1[C:11]#[N:12])=[O:7]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14986274HCID 14986274, compound

Product 1

HCID 14986276HCID 14986276, compoundYield 54.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-(acetoxyacetylamino)-6-morpholinobenzonitrile (3 g) in methanol (200 ml) is added dropwise 28% aqueous ammonia (10 ml). The mixture is stirred at room temperature for 1 hour, and thereafter, the solvent is distilled off under reduced pressure. The resulting residue is recrystallized from ethanol-water to give the title compound (1.4 g) having the following physical properties.

Workup

  1. distillationthe solvent is distilled off under reduced pressure
  2. customThe resulting residue is recrystallized from ethanol-water

Sources & evidence

ORD record
ord-92ca61aeed364cfd99a60ebe2e4b3071
Source dataset
uspto-grants-1991_08
Patent number
US05041462

Reaction notes

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