2-Chlorobenzenesulfonamide → HCID 19995021, compound

HRID 2248780Notes

Reaction equation

[O:1]1[CH2:6][CH2:5][N:4]([C:7]([NH:9][CH2:10][CH2:11][C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[N:17]([CH3:21])[CH:16]=[C:15]3[CH2:22][C:23]2[CH:31]=[CH:30][C:26]([C:27]([OH:29])=O)=[CH:25][C:24]=2[O:32][CH3:33])=[O:8])[CH2:3][CH2:2]1.[Cl:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=1[S:41]([NH2:44])(=[O:43])=[O:42]>>[O:1]1[CH2:2][CH2:3][N:4]([C:7]([NH:9][CH2:10][CH2:11][C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[N:17]([CH3:21])[CH:16]=[C:15]3[CH2:22][C:23]2[CH:31]=[CH:30][C:26]([C:27]([NH:44][S:41]([C:36]3[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=3[Cl:34])(=[O:43])=[O:42])=[O:29])=[CH:25][C:24]=2[O:32][CH3:33])=[O:8])[CH2:5][CH2:6]1

Participants

Reactant 2

HCID 814102-Chlorobenzenesulfonamide

HCID 19994987HCID 19994987, compound

Product 1

HCID 19995021HCID 19995021, compound

Procedure

Using a similar procedure to that described in Example 2, part c, except starting from 4-[5-[2-[(morpholinocarbonyl)amino]ethyl]-1-methylindol-3-ylmethyl]-3-methoxybenzoic acid, and using 2-chlorophenylsulfonamide instead of 2-methylphenylsulfonamide, the title compound was obtained (45%) as a white solid; mp 175°-181° C.

Sources & evidence

ORD record: ord-7fbb56d764b549fc86e25ad4a25e8258
Source dataset: uspto-grants-1991_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05041460

Reaction notes

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