HRID2248785

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81410

2-Chlorobenzenesulfonamide

C6H6ClNO2S

结构：COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(CC(C)NC(=O)N(C)C)cc12

HCID57195283

未命名化合物

PRODUCTS

生成物

结构：COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cc1cn(C)c2ccc(CC(C)NC(=O)N(C)C)cc12

HCID57020800

未命名化合物

PROCEDURE

实验过程

Using a similar procedure to that described in Example 2, part c, except starting from 4-[5-[2-(N',N'-dimethylureido)propyl]-1-methylindol-3-ylmethyl]- 3-methoxybenzoic acid, and using 2-chlorophenylsulfonamide instead of 2-methylphenylsulfonamide, the title compound was obtained (88%) as a white solid; mp 131°-136° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b7475bf950634a30a2c723532b5a469b
来源数据集: uspto-grants-1991_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05041460
来源说明: uspto-grants-1991_08

反应 SMILES

[CH3:1][N:2]([CH3:31])[C:3](=[O:30])[NH:4][CH:5]([CH3:29])[CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH3:16])[CH:11]=[C:10]2[CH2:17][C:18]1[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][C:19]=1[O:27][CH3:28].[Cl:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[S:39]([NH2:42])(=[O:41])=[O:40]>>[CH3:31][N:2]([CH3:1])[C:3](=[O:30])[NH:4][CH:5]([CH3:29])[CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH3:16])[CH:11]=[C:10]2[CH2:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([NH:42][S:39]([C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=2[Cl:32])(=[O:41])=[O:40])=[O:23])=[CH:20][C:19]=1[O:27][CH3:28]