2-Chlorobenzenesulfonamide → HCID 57287804, compound

HRID 2248787Notes

Reaction equation

[Cl:1][C:2]1[N:3]([CH3:32])[C:4]2[C:9]([C:10]=1[CH2:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](O)=[O:17])=[CH:14][C:13]=1[O:21][CH3:22])=[CH:8][C:7]([CH2:23][CH:24]([NH:26][C:27]([N:29]([CH3:31])[CH3:30])=[O:28])[CH3:25])=[CH:6][CH:5]=2.[Cl:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=1[S:40]([NH2:43])(=[O:42])=[O:41]>>[Cl:1][C:2]1[N:3]([CH3:32])[C:4]2[C:9]([C:10]=1[CH2:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([NH:43][S:40]([C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][C:34]=3[Cl:33])(=[O:42])=[O:41])=[O:17])=[CH:14][C:13]=1[O:21][CH3:22])=[CH:8][C:7]([CH2:23][CH:24]([NH:26][C:27]([N:29]([CH3:31])[CH3:30])=[O:28])[CH3:25])=[CH:6][CH:5]=2

Participants

Reactant 2

HCID 814102-Chlorobenzenesulfonamide

HCID 57268493HCID 57268493, compound

Product 1

HCID 57287804HCID 57287804, compound

Procedure

Using a similar procedure to that described in Example 2, part c, except starting from 4-[2-chloro-5-[2-(N',N'-dimethylureido)propyl]-1-methylindol-3-ylmethyl]-3-methoxybenzoic acid, and using 2-chlorophenylsulfonamide instead of 2-methylphenylsulfonamide, the title compound was obtained (47%) as a white solid; mp 126°-136° C.

Sources & evidence

ORD record: ord-55099b601a0c49d1af67ec4f19f06dea
Source dataset: uspto-grants-1991_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05041460

Reaction notes

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