5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → 2-[2-(5-Dimethylaminomethyl-2-furylmethylthio)ethylamino]-5-(1-(3-pyridyl)ethyl)-4-pyrimidone

HRID 224879Notes

Reaction equation

HRID 224879 reaction equation
CS[C:3]1[NH:8][C:7](=[O:9])[C:6]([CH:10]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[CH3:11])=[CH:5][N:4]=1.[CH3:18][N:19]([CH2:21][C:22]1[O:26][C:25]([CH2:27][S:28][CH2:29][CH2:30][NH2:31])=[CH:24][CH:23]=1)[CH3:20]>N1C=CC=CC=1>[CH3:20][N:19]([CH2:21][C:22]1[O:26][C:25]([CH2:27][S:28][CH2:29][CH2:30][NH:31][C:3]2[NH:8][C:7](=[O:9])[C:6]([CH:10]([C:12]3[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=3)[CH3:11])=[CH:5][N:4]=2)=[CH:24][CH:23]=1)[CH3:18]

Participants

4

Reactant 2

HCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamineHCID 135053092-Methylthio-5-[1-(3-pyridyl)ethyl]-4-pyrimidone

Product 1

HCID 202132762-[2-(5-Dimethylaminomethyl-2-furylmethylthio)ethylamino]-5-(1-(3-pyridyl)ethyl)-4-pyrimidone

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Equimolar amounts of 2-methylthio-5-[1-(3-pyridyl)ethyl]-4-pyrimidone and 2-(5-dimethylaminomethyl-2-furylmethylthio)ethylamine in pyridine are boiled under reflux for 48 hours and evaporated to dryness. The residue is purified to give 2-[2-(5-dimethylaminomethyl-2-furylmethylthio)ethylamino]-5-(1-(3-pyridyl)ethyl)-4-pyrimidone.

Workup

  1. temperatureunder reflux for 48 hours
  2. customevaporated to dryness
  3. customThe residue is purified

Sources & evidence

ORD record
ord-290a30cbc776403d977e060fa8be9500
Source dataset
uspto-grants-1980_11
Patent number
US04234588

Reaction notes

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