反应详情

A mixture of 4 parts of ethyl 4-[[[[4-[(2-furanylmethyl)amino]-5-pyrimidinyl]amino]thioxomethyl]-amino]-1-piperidinecarboxylate, 6 parts of mercury(II) oxide and 80 parts of ethanol was stirred for 2 hours at reflux temperature. The whole was filtered while hot over Hyflo® and the filtrate was evaporated. The residue was crystallized from a mixture of acetonitrile and ethanol. The product was filtered off and dried, yielding 0.8 parts (21.5%) of ethyl 4-[[9-(2-furanylmethyl)-9H-purin-8-yl]amino]-1-piperidinecarboxylate; mp. 171.9° C. (compound 7).

1. temperatureat reflux temperature
2. filtrationThe whole was filtered while hot over Hyflo®
3. customthe filtrate was evaporated
4. customThe residue was crystallized from a mixture of acetonitrile and ethanol
5. filtrationThe product was filtered off
6. customdried