化工社化工社 化学情報印刷レポート · 研究参考用
6-Methoxypyridine-3-carbaldehyde → Ethyl 3-(6-methoxy-3-pyridyl)acrylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Methoxypyridine-3-carbaldehyde | HCID 3364576 | — |
| 反応物 | Propanedioic acid, monoethyl ester | HCID 3595298 | — |
| 触媒 | Piperidine | HCID 8082 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | Ethyl 3-(6-methoxy-3-pyridyl)acrylate | HCID 53930754 | 79.2% |
反応手順
A mixture of 6-methoxypyridine-3-carboxaldehyde (2.34 g), monoethyl malonate (4.51 g), pyridine (12 ml) and piperidine (6 drops) was heated under reflux for 5 hours and was evaporated to an oil. This oil was partitioned between ether and dilute aqueous ammonia. The ether layer was washed with water and evaporated to an oil which crystallised on standing to give ethyl 3-(6-methoxy-3-pyridyl)acrylate (2.8 g, 79%) m.p. 49°-52°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04234588 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-82b636fa743a4d50919b942bcbffa88e |
| 出典メモ | uspto-grants-1980_11 |