HCID 19995061, compound → 4-Aminophenyl trifluoromethyl sulphone

HRID 2248835Notes

Reaction equation

HRID 2248835 reaction equation
[S:1]([C:8]1[CH:28]=[CH:27][C:11]([N:12](CC2C=CC=CC=2)CC2C=CC=CC=2)=[CH:10][CH:9]=1)([C:4]([F:7])([F:6])[F:5])(=[O:3])=[O:2]>C(O)=O.CO.[Pd]>[S:1]([C:8]1[CH:28]=[CH:27][C:11]([NH2:12])=[CH:10][CH:9]=1)([C:4]([F:5])([F:6])[F:7])(=[O:3])=[O:2]

Participants

4

Reactant 1

HCID 19995061HCID 19995061, compound

Product 1

HCID 1363154-Aminophenyl trifluoromethyl sulphone

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 18963719Formic acid methanolSolvent2×

Procedure

To a stirred solution of 0.1 g of palladium black in 4.4% formic acid-methanol is added 37.3 g (0.1 mole) of 4-triflyl-N,N-dibenzylaniline in 4.4% formic acid-methanol. The reaction is stirred under an argon atmosphere until complete as indicated by thin layer chromatographic analysis. The catalyst is removed by filtration and washed with additional portions of methanol followed by water. The combined methanol and water washes are evaporated, and compound B is purified by distillation.

Workup

  1. customThe catalyst is removed by filtration
  2. washwashed with additional portions of methanol
  3. customThe combined methanol and water washes are evaporated
  4. distillationcompound B is purified by distillation

Sources & evidence

ORD record
ord-907731a26c5448fca15b25c70399ed9c
Source dataset
uspto-grants-1991_08
Patent number
US05041510

Reaction notes

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