Water → HCID 19995062, compound

HRID 2248836Notes

Reaction equation

HRID 2248836 reaction equation
[S:1]([C:8]1[CH:14]=[CH:13][C:11]([NH2:12])=[CH:10][CH:9]=1)([C:4]([F:7])([F:6])[F:5])(=[O:3])=[O:2].[N:15]([O-])=O.[Na+].O.[F:20][P-:21]([F:26])([F:25])([F:24])([F:23])[F:22].[Na+]>Cl.O>[F:20][P-:21]([F:26])([F:25])([F:24])([F:23])[F:22].[S:1]([C:8]1[CH:14]=[CH:13][C:11]([N+:12]#[N:15])=[CH:10][CH:9]=1)([C:4]([F:5])([F:6])[F:7])(=[O:3])=[O:2]

Participants

6

Reactant 4

HCID 962WaterHCID 1363154-Aminophenyl trifluoromethyl sulphoneHCID 5147921Sodium hexafluorophosphateHCID 23668193Sodium Nitrite

Product 1

HCID 19995062HCID 19995062, compound

Reagents, catalysts & solvents 1

HCID 21885828Hydrate;hydrochlorideSolvent

Procedure

A stirred solution of 22.5 g (0.1 mole) of 4-triflylaniline in HCl/H2O (50:50) is cooled in an ice bath to about 10° C., and 6.9 g (1 mole) of sodium nitrite in a minimum amount of water is added slowly to the mixture, while maintaining the temperature below 10° C. The reaction then is warmed to room temperature and stirred for 15 additional minutes. Sodium hexafluorophosphate (16.7 g, 0.1 mole) is added in portions, and the mixture is stirred for 10 minutes more. The solid product is collected by vacuum filtration and dried.

Workup

  1. temperaturewhile maintaining the temperature below 10° C
  2. customThe reaction
  3. stirringthe mixture is stirred for 10 minutes more
  4. filtrationThe solid product is collected by vacuum filtration
  5. customdried

Sources & evidence

ORD record
ord-cd2e0268215448d19f62f9243c4be3cf
Source dataset
uspto-grants-1991_08
Patent number
US05041510

Reaction notes

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