HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → 2-[2-(5-Dimethylaminomethyl-2-furylmethylthio)ethylamino]-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine | HCID 162203 | — |
| Reactant | 2-Nitroamino-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone | HCID 12783832 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-[2-(5-Dimethylaminomethyl-2-furylmethylthio)ethylamino]-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone | HCID 14975745 | — |
Reaction Steps
An equimolar mixture of 2-nitroamino-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone and 2-(5-dimethylaminomethyl-2-furylmethylthio)ethylamine are refluxed in ethanol for 18 hours and evaporated to dryness. The residue is triturated with water and recrystallised to give 2-[2-(5-dimethylaminomethyl-2-furylmethylthio)ethylamino]-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04234588 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-07d496a021e843499a94b5ac8c826f83 |
| Source note | uspto-grants-1980_11 |