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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2248875Generated: November 2, 2026

3-Hydroxybenzyl alcohol → Benzenemethanol, 3-(2-quinolinylmethoxy)-

https://huagongshe.com/reaction/2248875

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Hydroxybenzyl alcoholHCID 102—
ReactantSodium HydroxideHCID 14798—
Reactant2-(Chloromethyl)quinoline hydrochlorideHCID 3083823—
SolventDimethyl SulfoxideHCID 679—
ProductBenzenemethanol, 3-(2-quinolinylmethoxy)-HCID 14650410103.2%

Reaction Steps

20.0g (93.5 mmoles) of 2-chloromethylquinoline hydrochloride, 11.6 g (93.5 mmoles) of 3-hydroxybenzyl alcohol and 7.48 g (186.42 mmoles) of powdered sodium hydroxide are combined in 56 ml of dimethylsulfoxide. After stirring room temperature for 24 hours the mixture is poured into ice-water and the resulting solid is collected and dried to give 25.6 g of 3-(2-quinolinylmethyloxy)benzyl alcohol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05041453
Source datasetuspto-grants-1991_08
ORD IDord-a285d952d4a8416d8756545c786747d3
Source noteuspto-grants-1991_08