HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-Cyano-6-(3-(quinolin-2-ylmethyloxy)benzyloxy)benzoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-(3-Chloromethylphenoxy)methylquinoline | HCID 14501706 | — |
| Reactant | 2-Cyano-6-hydroxybenzoxazole | HCID 19994771 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-Cyano-6-(3-(quinolin-2-ylmethyloxy)benzyloxy)benzoxazole | HCID 19994748 | — |
Reaction Steps
To 2-cyano-6-hydroxybenzoxazole (11.87 mmoles) and 2-((3-chloromethylphenoxy)methyl)quinoline (11.87 mmoles) in dimethylsulfoxide (20 ml) is added powdered sodium hydroxide (0.475 q). After one week the reaction mixture is poured into ice water and the resulting precipitate collected and purified by HPLC to give 2-cyano-6-(3-(quinolin-2-ylmethyloxy)benzyloxy)-benzoxazole which is used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05041453 |
| Source dataset | uspto-grants-1991_08 |
| ORD ID | ord-183aa115a0a74806a443c5e9636c2d0b |
| Source note | uspto-grants-1991_08 |