Water → HCID 19994727, compound

HRID 2248885Notes

Reaction equation

HRID 2248885 reaction equation
C([C:3]1[C:14]([Cl:15])=[C:13]([OH:16])[C:6]2[N:7]=[C:8]([C:10]([OH:12])=[O:11])[O:9][C:5]=2[CH:4]=1)C.O>C(O)(=O)C>[Cl:15][C:14]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]([OH:12])=[O:11])=[N:7][C:6]=2[C:13]=1[OH:16]

Participants

4

Reactant 2

HCID 962WaterHCID 19994683HCID 19994683, compound

Product 1

HCID 19994727HCID 19994727, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Ethyl 5-chloro-4-hydroxybenzoxazole-2-carboxylic acid is dissolved in glacial acetic acid and water (5:1) and the solution refluxed for 4 hours. This is cooled and the resulting solid collected and washed with water to give 5-chloro-4-hydroxybenzoxazole-2-carboxylic acid.

Workup

  1. temperatureThis is cooled
  2. customthe resulting solid collected
  3. washwashed with water

Sources & evidence

ORD record
ord-a5ae9ced93904d708c238af51df190b4
Source dataset
uspto-grants-1991_08
Patent number
US05041453

Reaction notes

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