HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → n-Propyl 5-chloro-4-(4-(quinolin-2-ylmethyloxy)benzyloxy)benzoxazole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | 2-(4-Chloromethylphenoxy)methylquinoline | HCID 14774163 | — |
| Reactant | HCID 19994790 | HCID 19994790 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | n-Propyl 5-chloro-4-(4-(quinolin-2-ylmethyloxy)benzyloxy)benzoxazole-2-carboxylate | HCID 53653363 | — |
Reaction Steps
0.78 g of 2-(4-chloromethylphenoxy)methylquinoline, 6.84 g of n-propyl 5-chloro-4-hydroxybenzoxazole-2carboxylate and a catalytic amount of potassium iodide are combined in 50 ml of acetone and 2 ml of dimethylformamide, and refluxed for 19 hours. The crude solid obtained on cooling is purified by flash chromatography to give n-propyl 5-chloro-4-(4-(quinolin-2-ylmethyloxy)benzyloxy)benzoxazole-2-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05041453 |
| Source dataset | uspto-grants-1991_08 |
| ORD ID | ord-d3ac78475dbe49ff9993f407b9c8f4c7 |
| Source note | uspto-grants-1991_08 |