Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-[(Quinolin-2-yl)methoxy]phenol | HCID 10988737 | — |
| Reactant | 2-Benzoxazolecarboxylic acid, 6-(bromomethyl)-, ethyl ester | HCID 19994703 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 19994693 | HCID 19994693 | — |
Reaction Steps
0.8 g of 4-(2-quinolinylmethyloxy)phenol, 0.89 g of ethyl 6-bromomethylbenzoxazole-2-carboxylate and 0.44 g of potassium carbonate are combined in 15 ml of dimethylformamide and heated at 70° C. for 18 hours. The mixture is poured into water and the aqueous mixture extracted with ethyl acetate. The organic solution is dried and evaporated and the resulting crude product is purified by column chromatography on silica gel to give ethyl 6-(4-(quinolin-2-ylmethyloxy)phenoxymethyl)-benzoxazole-2carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05041453 |
|---|
| Source dataset | uspto-grants-1991_08 |
|---|
| ORD ID | ord-c4ffca03897b4d02857c2e7656c76aee |
|---|
| Source note | uspto-grants-1991_08 |
|---|
