Sodium Hydroxide → HCID 178477872, compound

Participants

Reaction Conditions

Reaction Steps

A solution-suspension of (E)-2-cyano-6-[3-(7-chloro-2-quinolinylethenyl)phenoxymethyl]benzoxazole (950 mg, 2.17 mmol), sodium azide (432.1 mg, 6.51 mmol) and ammonium chloride (348.1 mg, 6.51 mmol) in DMF (15 ml) is heated to 100° C. for 7 hours and stirred at room temperature for 12 hours. The mixture is poured over ice-water and the pH is adjusted to 10 with 1N NaOH. The aqueous mixture is washed with ether and the pH adjusted to 4 with 1N-HCl. The precipitated solid is filtered and washed successively with water, ethanol and methylene chloride. Recrystallization from DMF affords (E)-5-(6-[3-(7-chloro-2-quinolinyl-ethenyl)phenoxymethyl ]benzoxazol-2-yl)tetrazole. (M.P. 272° C. (dec.))

Provenance & Evidence