Lithium hydroxide, monohydrate → 3-Methyl 5-[3(2-quinolinylmethyloxy)-benzyloxy]benzo(b)thiophene-2-carboxylic acid

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Reaction Steps

To a stirred solution of methyl-3-methyl-5-[3-(2quinolinylmethyloxy)benzyloxy]benzo(b)thiophene-2-carboxylate (355 mg, 0.76 mmol) in THF (10 ml), methanol (10 ml) and water (10 ml) at room temperature is added lithium hydroxide monohydrate (156 mg, 3.71 mmol). The resulting solution is stirred for 16 hours and concentrated. The residue is suspended in water and washed with ether. The aqueous layer is acidified to pH 3. The precipitated solid is filtered, washed with water and methylene chloride and dried to provide 3-methyl 5-[3(2-quinolinylmethyloxy)-benzyloxy]benzo(b)thiophene -2-carboxylic acid.

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