Benzoxazole → HCID 54008937, compound

HRID 2248909Notes

Reaction equation

[C:1]([C:3]1[O:4][C:5]2[CH:11]=[CH:10][C:9]([CH:12]([OH:39])[CH:13]([S:32][CH2:33][CH2:34][C:35]([O:37]C)=[O:36])[C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH2:21][C:22]4[CH:31]=[CH:30][C:29]5[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=5)[N:23]=4)[CH:15]=3)=[CH:8][C:6]=2[N:7]=1)#[N:2].O1C2C=CC=CC=2N=C1>>[C:1]([C:3]1[O:4][C:5]2[CH:11]=[CH:10][C:9]([CH:12]([OH:39])[CH:13]([S:32][CH2:33][CH2:34][C:35]([OH:37])=[O:36])[C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH2:21][C:22]4[CH:31]=[CH:30][C:29]5[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=5)[N:23]=4)[CH:15]=3)=[CH:8][C:6]=2[N:7]=1)#[N:2]

Participants

Reactant 2

HCID 9228Benzoxazole

HCID 19994688HCID 19994688, compound

Product 1

HCID 54008937HCID 54008937, compound

Procedure

When the 1-hydroxy ester obtained in Example 64, Step 2, above, is substituted for the ester in Example 31, 1-cyano-5-(1-hydroxy-2-((2-carboxyethyl)thio) -2-(3-quinolin-2-yl-methyloxy)phenyl)ethyl)benzoxazole is obtained.

Workup

customis obtained

Sources & evidence

ORD record: ord-492ed774bb5648bc9dbafa441ba07b07
Source dataset: uspto-grants-1991_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05041453

Reaction notes

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