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HRID2248945

反应详情

EQUATION

反应方程式

HRID 2248945 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)OC[C@H]1OC(OC(C)=O)[C@H](OC(C)=O)[C@@H]1OC(C)=O
HCID9797055

D-Ribofuranose, 1,2,3,5-tetraacetate

C13H18O9

结构：Nc1nc2[nH]c(=O)sc2c(=O)[nH]1
HCID135743639

5-Amino[1,3]thiazolo[4,5-d]pyrimidine-2,7(3H,4H)-dione

C5H4N4O2S

PRODUCTS

生成物

1
结构：CC(=O)OC[C@H]1O[C@@H](n2c(=O)sc3c(=O)[nH]c(N)nc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O
HCID135434785

5-Amino-3-(2,3,5-tri-O-acetyl-beta-ribofuranosyl)thiazolo(4,5-d)pyrimidine-2,7-dione

C16H18N4O9S

PROCEDURE

实验过程

Compound 4 (10 g, 54.4 mmol) was glycosylated exactly as described for the synthesis of 6 except that the sugar used in this case was the 1,2,3,5-tetra-O-acetyl-D-ribofuranose (20.7 g, 65.1 mmol). After the usual workup the crude residue was flash chromatographed on silica gel using 10% methanol in dichloromethane. Yield of pure material 7.1 g (29%) as a dry foam or amorphous solid.

WORKUP

后处理

  1. customchromatographed on silica gel using 10% methanol in dichloromethane