HCID 131716986, compound → HCID 67924778, compound

Participants

Reaction Steps

A mixture of 6.00 g of compound B from Example II and 6.03 g of 5% palladium on charcoal in 100 mL of ethanol was treated with hydrogen gas at a constant pressure of 50 psi for 5.0 hours at room temperature. The reaction was filtered through celite and concentrated under reduced pressure to provide 3.52 g of crude product. Recrystallization from aqueous ethanol furnished material with the following characteristics: mp 116°-8° C.; IR (KBr) 2993, 2860, 1660, 1540, 1225, 849 cm-1 ; 1H-NMR (DMSO-d6) δ 1.07 (d), 1.35 (brm), 6.11 (s), 6.18 (s), 7.00 (br); 13C-NMR (DMSO) δ 21.65, 23.57, 25.09, 29.36, 31.39, 35.40, 43.64, 65.88, 69.64, 100.55, 104.84, 110.04, 147.31, 161.58, 172.65.

Provenance & Evidence