Bromine → HCID 54254433, compound

Participants

Reaction Steps

m-Methylthioacetophenone (7.14 g, 43 mmol) was dissolved in chloroform (100 ml). Aluminium chloride (catalytic amount) and bromine (2.2 ml, 43 mmol) were added and stirred for 1 h. The reaction was quenched with aqueous sodium chloride-sodium bicarbonate and the organic layer separated, dried (MgSO4) and evaporated under reduced pressure. The residue was taken up in ethyl acetate, washed with aqueous sodium bicarbonate, then brine, dried (MgSO4) and evaporated under reduced pressure to yield m-Methylthiophenacyl bromide (7.64 g, 73%); δH(CDCl3) 7.1-7.9(4H,m, aryl), 4.40(2H,S,CH2), 2.45(3H,S,SCH3H).

Provenance & Evidence